Researchers Propose Five Clusters Of Diabetes Instead Of Two Types

Researchers Propose Five Clusters Of Diabetes Instead Of Two Types

Researchers Propose Five Clusters Of Diabetes Instead Of Two Types

However, this study alone is not sufficient to lead to changes in diabetes treatment guidelines, as it was only based on groups of diabetes patients in Scandinavia. Obesity and lack of physical activity are two of the most common causes of this form of diabetes.

Most people with diabetes - between 85% and 90% - have type 2 diabetes, in which the body does not produce enough insulin, or the insulin they have does not work properly. Subgroup classification was validated in three independent cohorts.

They said a refined classification could provide a powerful tool to individualise treatment and identify individuals with increased risk of complications at diagnosis, such as nerve damage, cardio vascular disease or skin conditions.

The new study offers a new division for diabetes, and identifies five clusters of patients.

Clusters 3 and 4 describe diabetes in generally overweight individuals with insulin resistance, but those in Cluster 4 are metabolically closer to normal compared to those in Cluster 3.

Cluster 2 are severely insulin-deficient patients who were likewise young and healthy, and struggled with insulin, but the cause was not immune system failure.

Researchers from Lund University Diabetes Centre in Sweden and the Institute for Molecular Medicine in Finland gathered data on nearly 15,000 patients from across five cohorts in both countries.

The results have been published in The Lancet: Diabetes and Endocrinology. As in cluster 1, strikes young and healthy people, but the immune system isn't at fault.

The anti-inflammatory drug, lefluonamide, lowered blood glucose levels and reversed insulin resistance in mouse models of type-2 diabetes, which suggests that this therapy could be repurposed as an effective antidiabetic treatment, particularly suitable for patients with both diabetes and rheumatoid arthritis.

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There were patients whose cells also stopped producing insulin, but not due to their immune system; they were often young and in otherwise good shape.

Cluster 5: Mild age related diabetes, affecting 39.6 per cent of patients. The study found that people with this type most commonly developed eye disease.

Still, the findings seem to be a positive step toward improved treatment of diabetes, which affects more than 420 million people worldwide.

In addition to a more refined classification, the researchers also discovered that the different groups are more or less at risk of developing various secondary diseases.

Stemming from the All New Diabetics in Scania cohort, 8,980 Swedish patients newly diagnosed with diabetes were included in the hierarchical clustering.

The researchers also want similar studies in China and India with people of different ethnic backgrounds. This group had the largest proportion of patients prescribed insulin (42%), as well as the shortest time to insulin use (HR 26.87 versus cluster 5, 95% CI 21.17-34.11).

This is a valuable study that suggests the diagnosis of diabetes may not be as simple as just types 1 and 2.

They believe the more precise groupings - each genetically distinct - will aid diagnosis, help tailor treatments and lead to precision medicines.

Researchers did not observe between-cluster differences for age- and sex-adjusted coronary event and stroke risk, and no genetic variant was associated with all the clusters.

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